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KMID : 0616120070380010095
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Korean Journal of Pharmacognosy
2007 Volume.38 No. 1 p.95 ~ p.99
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(Cancer Chemopreventive Activity of the Rhizome Extract of Alpinia officinarum)
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Ku Kang-Mo
Song Kyung-Sik
Jang young-Jin
Kim Min-Keun
Kim Gil-Wung
Kang Young-Hwa
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Abstract
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In order to find novel cancer chemopreventive agents, quinone reductase (QR) inductive activity of methanol extract of herbal medicines was examined using murine hepatoma, hepa1c1c7 cells. QR has been used as an anticarcinogenic marker enzyme in cancer chemoprevention study. The methanol extract of Alpinia officinarum (Zingiberace) showed showed significantly strong quinone reductase inductive activity compared to the control group. The methanol extract of Alpinia officinarum was successively fractionated with various solvents according to polarity. Hexane, ethyl acetate, buthanol and water fractions were obtained and theirs activities were assessed. The QR inductive effect was moved to the ethyl acetate fraction and was highly increased. The CD (concentration required to double the specific activity of QR) value of ethyl acetate fraction was 8.6 {mu}g/mL. Alpinia officinarum also showed strong antioxidant activity. These results suggest that Alpinia officinarum can be developed as cancer chemopreventive agent.
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KEYWORD
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Cancer chemoprevention, Quinone reductase, Antioxidant, Alpinia officinarum
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